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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/21764
Title: Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex
Authors: Leena Suntornsuk
Keiichi Koizumi
Yurika Saitoh
Eliane Shizuka Nakamura
Naparat Kammasud
Opa Vajaragupta
Ikuo Saiki
Mahidol University
University of Toyama
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2004
Citation: Journal of Traditional Medicines. Vol.21, No.2 (2004), 94-99
Abstract: We investigated the anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative (curcumin ED) and curcumin ethylenediamine manganese complex (curcumin EDMn) through the inhibition of the formation of tube-like structures by human umbilical vascular endothelial cells (HUVEC). Curcumin, curcumin ED, curcumin EDMn did not show cytotoxicity to HUVEC at concentrations equal and lower than 10 μM. At the concentration of 10 μM, curcumin, curcumin ED and curcumin EDMn inhibited the tube formation by approximately 94%, 40% and 65%, respectively. These results suggest that curcumin ED and curcumin EDMn might be useful as anti-angiogenic drugs in addition to their anti-lipid peroxidase and superoxide dismutase activities as described in our previous studies. © 2004, Medical and Pharmaceutical Society for WAKAN-YAKU. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85009555963&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/21764
ISSN: 18813747
18801447
Appears in Collections:Scopus 2001-2005

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