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Title: Opioid modulation of GABA release in the rat inferior colliculus
Authors: Walaiporn Tongjaroenbungam
Nopporn Jongkamonwiwat
Joanna Cunningham
Pansiri Phansuwan-Pujito
Hilary C. Dodson
Andrew Forge
Piyarat Govitrapong
Stefano O. Casalotti
Mahidol University
King's College London
Srinakharinwirot University
Keywords: Neuroscience
Issue Date: 7-Sep-2004
Citation: BMC Neuroscience. Vol.5, (2004)
Abstract: Background: The inferior colliculus, which receives almost all ascending and descending auditory signals, plays a crucial role in the processing of auditory information. While the majority of the recorded activities in the inferior colliculus are attributed to GABAergic and glutamatergic signalling, other neurotransmitter systems are expressed in this brain area including opiate peptides and their receptors which may play a modulatory role in neuronal communication. Results: Using a perfusion protocol we demonstrate that morphine can inhibit KCl-induced release of [3H]GABA from rat inferior colliculus slices. DAMGO ([D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin) but not DADLE ([D-Ala2, D-Leu5]-enkephalin or U69593 has the same effect as morphine indicating that μ rather than δ or κ opioid receptors mediate this action. [3H]GABA release was diminished by 16%, and this was not altered by the protein kinase C inhibitor bisindolylmaleimide I. Immunostaining of inferior colliculus cryosections shows extensive staining for glutamic acid decarboxylase, more limited staining for μ opiate receptors and relatively few neurons co-stained for both proteins. Conclusion: The results suggest that μ-opioid receptor ligands can modify neurotransmitter release in a sub population of GABAergic neurons of the inferior colliculus. This could have important physiological implications in the processing of hearing information and/or other functions attributed to the inferior colliculus such as audiogenic seizures and aversive behaviour. © 2004 Tongjaroenbungam et al; licensee BioMed Central Ltd.
ISSN: 14712202
Appears in Collections:Scopus 2001-2005

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