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dc.contributor.authorThida Chanyachukulen_US
dc.contributor.authorKrongtong Yoovathawornen_US
dc.contributor.authorWatchareewan Thongsaarden_US
dc.contributor.authorSukumal Chongthammakunen_US
dc.contributor.authorPanida Navasumriten_US
dc.contributor.authorJutamaad Satayavivaden_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherSrinakharinwirot Universityen_US
dc.contributor.otherChulabhorn Research Instituteen_US
dc.date.accessioned2018-07-24T03:57:04Z-
dc.date.available2018-07-24T03:57:04Z-
dc.date.issued2004-05-02en_US
dc.identifier.citationToxicology Letters. Vol.150, No.3 (2004), 259-269en_US
dc.identifier.issn03784274en_US
dc.identifier.other2-s2.0-1942517470en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1942517470&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/21804-
dc.description.abstractAlterations of motor behavioral patterns and monoamine contents in the discrete rat brain areas after acute paraquat exposure (3, 5, 10, 20mg/kg, s.c.) have been studied. The results showed that paraquat at the doses of 5, 10, and 20mg/kg significantly reduced locomotive, stereotypic, and rotational behaviors. Significant decreases of norepinephrine (NE) contents in cortex and hypothalamus, as well as striatal contents of dopamine (DA) and its acidic metabolites, were detected. In addition, L-valine (200mg/kg, i.p.) significantly attenuated paraquat-induced toxicity at moderate dose (5mg/kg) but not at high dose (20mg/kg). The results provide evidence that paraquat can enter the brain as illustrated by the alterations in the motor behavioral pattern and neurochemical contents. Furthermore, the attenuation effect of L-valine against systemic administration of paraquat-induced motor behaviors was detected, with a slightly protective effect on paraquat-induced neurochemical alterations. © 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1942517470&origin=inwarden_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleAttenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivoen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.toxlet.2004.02.007en_US
Appears in Collections:Scopus 2001-2005

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