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Title: Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo
Authors: Thida Chanyachukul
Krongtong Yoovathaworn
Watchareewan Thongsaard
Sukumal Chongthammakun
Panida Navasumrit
Jutamaad Satayavivad
Mahidol University
Srinakharinwirot University
Chulabhorn Research Institute
Keywords: Pharmacology, Toxicology and Pharmaceutics
Issue Date: 2-May-2004
Citation: Toxicology Letters. Vol.150, No.3 (2004), 259-269
Abstract: Alterations of motor behavioral patterns and monoamine contents in the discrete rat brain areas after acute paraquat exposure (3, 5, 10, 20mg/kg, s.c.) have been studied. The results showed that paraquat at the doses of 5, 10, and 20mg/kg significantly reduced locomotive, stereotypic, and rotational behaviors. Significant decreases of norepinephrine (NE) contents in cortex and hypothalamus, as well as striatal contents of dopamine (DA) and its acidic metabolites, were detected. In addition, L-valine (200mg/kg, i.p.) significantly attenuated paraquat-induced toxicity at moderate dose (5mg/kg) but not at high dose (20mg/kg). The results provide evidence that paraquat can enter the brain as illustrated by the alterations in the motor behavioral pattern and neurochemical contents. Furthermore, the attenuation effect of L-valine against systemic administration of paraquat-induced motor behaviors was detected, with a slightly protective effect on paraquat-induced neurochemical alterations. © 2004 Elsevier Ireland Ltd. All rights reserved.
ISSN: 03784274
Appears in Collections:Scopus 2001-2005

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