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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/21831
Title: Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei
Authors: Matthew T.G. Holden
Richard W. Titball
Sharon J. Peacock
Ana M. Cerdeño-Tárraga
Timothy Atkins
Lisa C. Crossman
Tyrone Pitt
Carol Churcher
Karen Mungall
Stephen D. Bentley
Mohammed Sebaihia
Nicholas R. Thomson
Mathalie Bason
Ifor R. Beacham
Karen Brooks
Katherine A. Brown
Nat F. Brown
Greg L. Challis
Inna Cherevach
Tracy Chillingworth
Ann Cronin
Ben Crossett
Paul Davis
David DeShazer
Theresa Feltwell
Audrey Fraser
Zahra Hance
Heidi Hauser
Simon Holroyd
Kay Jagels
Karen E. Keith
Mark Maddison
Sharon Moule
Claire Price
Michael A. Quail
Ester Rabbinowitsch
Kim Rutherford
Mandy Sanders
Mark Simmonds
Sirirurg Songsivilai
Kim Stevens
Sarinna Tumapa
Monkgol Vesaratchavest
Sally Whitehead
Corin Yeats
Bart G. Barrell
Petra C.F. Oyston
Julian Parkhill
Wellcome Trust Sanger Institute
Defence Science and Technology Laboratory
London School of Hygiene & Tropical Medicine
Nuffield Department of Clinical Medicine
Mahidol University
Central Public Health Laboratory
Griffith University
Imperial College London
The University of Warwick
U.S. Army Medical Research Institute of Infectious Diseases
Keywords: Multidisciplinary
Issue Date: 28-Sep-2004
Citation: Proceedings of the National Academy of Sciences of the United States of America. Vol.101, No.39 (2004), 14240-14245
Abstract: Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world and accounts for 20% of community-acquired septicaemias in northeastern Thailand where half of those affected die. Here we report the complete genome of B. pseudomallei, which is composed of two chromosomes of 4.07 megabase pairs and 3.17 megabase pairs, showing significant functional partitioning of genes between them. The large chromosome encodes many of the core functions associated with central metabolism and cell growth, whereas the small chromosome carries more accessory functions associated with adaptation and survival in different niches. Genomic comparisons with closely and more distantly related bacteria revealed a greater level of gene order conservation and a greater number of orthologous genes on the large chromosome, suggesting that the two replicons have distinct evolutionary origins. A striking feature of the genome was the presence of 16 genomic islands (GIs) that together made up 6.1% of the genome. Further analysis revealed these islands to be variably present in a collection of invasive and soil isolates but entirely absent from the clonally related organism B. mallei. We propose that variable horizontal gene acquisition by β. pseudomallei is an important feature of recent genetic evolution and that this has resulted in a genetically diverse pathogenic species.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=4644274415&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/21831
ISSN: 00278424
Appears in Collections:Scopus 2001-2005

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