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Title: A method to differentiate between anti-C1q antibodies and C1q-binding immune complexes using collagenase-digested solid phase C1q
Authors: Johannes E. Menzel
Othmar Scherak
Gernot Kolarz
Fritz Gamerith
Uriwan Youngchaiyud
Medizinische Universitat Wien, Instituts fur Immunologie
Ludwig Boltzmann Institute
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 25-Apr-1991
Citation: Journal of Immunological Methods. Vol.138, No.2 (1991), 165-171
Abstract: A method for the detection of circulating immune complexes in the presence of autoantibodies to C1q is described. Solid phase C1q-digestion with bacterial collagenase results in the elimination of the collagen-like region of C1q. Binding of model immune complexes to this modified solid phase C1q is practically unaltered, while reactivity of anti-C1q antibodies is abolished by this procedure. In conjunction with an ELISA using the collagen-like region of C1q as antigen this modified C1q solid phase assay may be used to determine immune complexes and anti-C1q antibodies in the sera of patients with autoimmune rheumatic diseases. © 1991.
ISSN: 00221759
Appears in Collections:Scopus 1991-2000

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