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Title: Antifertility effects of sulfapyridine on male hamsters
Authors: R. Weissenberg
C. Pholpramool
L. M. Lewin
Chaim Sheba Medical Center Israel
Mahidol University
Tel Aviv University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-1991
Citation: Andrologia. Vol.23, No.4 (1991), 269-271
Abstract: Summary. Sulfapyridine was administered to mature male golden hamsters either by impregnation in feed pellets, or by subcutaneous injection as a solution in dimethylsulfoxide. The average litter size for control males was 8.3 ± 3.3 (n = 13) vs. 4.2 ± 2.7 (n = 11) for sulfapyridine‐fed treated animals. Histology of the testis and epididymis was normal and sperm were normal in morphology and motility. Subcutaneous injection of sulfapyridine caused much more dramatic inhibition of male fertility than was achieved by feeding the drug. Sulfapyridine (750 mg/kg body weight in 0.2 ml DMSO) injected subcutaneously for 60 days was effective in reducing testis size and sperm quality. Histology of testes showed spermatogenic arrest at young spermatids. Two classes of animals were found in both sulfapyridine‐fed and ‐injected treatment groups. One class was relatively resistant to the antifertility effects of the drugs. This difference may reflect differing abilities of the animals to convert sulfapyridine to an active form or to excrete its metabolites. 1991 Blackwell Verlag GmbH
ISSN: 14390272
Appears in Collections:Scopus 1991-2000

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