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Title: Promotion of Rat Hepatocarcinogenesis by Praziquantel
Authors: Tomoyuki Shirai
Kim Dae Joong
Kazuo Hakoi
Witaya Thamavit
Chawalit Pairojkul
Toru Hoshiya
Ryohei Hasegawa
Nobuyuki Ito
Nagoya City University Medical School
Mahidol University
Khon Kaen University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-1991
Citation: Japanese Journal of Cancer Research. Vol.82, No.10 (1991), 1085-1088
Abstract: Praziquantel, the widely used anti‐helminthic agent, was investigated for hepatocarcinogenesis‐promoting potential using a medium‐term liver bioassay system for carcinogens. F344 male rats were given a single intraperitoneal injection of diethylnitrosamine (DEN, 200 mg/kg) and then starting 2 weeks later, received praziquantel in the diet at concentrations of 1.5 or 0.5%, or intragastrically at a dose of 1,500 mg/kg once a week for 6 weeks. Control groups received DEN or praziquantel alone. All rats were subjected to two‐thirds partial hepatectomy at week 3 and killed at week 8. Development of glutathione 5‐transferase placental form‐positive foci in the liver was significantly increased in terms of both number and area with the 1.5% dose, while only area was affected by the 0.5% dose. The results thus indicate that praziquantel at high dose has promoting potential in rat hepatocytic tumorigenesis. Copyright © 1991, Wiley Blackwell. All rights reserved
ISSN: 13497006
Appears in Collections:Scopus 1991-2000

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