Please use this identifier to cite or link to this item:
http://repository.li.mahidol.ac.th/dspace/handle/123456789/22012
Title: | Plant anticancer agents, XLVIII. New cytotoxic flavonoids from muntingia calabura roots |
Authors: | Norito Kaneda John M. Pezzuto D. Doel Soejarto A. Douglas Kinghorn Norman R. Farnsworth Thawatchai Santisuk Patoomratana Tuchinda Jinda Udchachon Vichai Reutrakul University of Illinois at Chicago Thailand Royal Forest Department Mahidol University |
Keywords: | Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics |
Issue Date: | 1-Jan-1991 |
Citation: | Journal of Natural Products. Vol.54, No.1 (1991), 196-206 |
Abstract: | From a cytotoxic Et2O soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1–7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1–12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on1H−1H COSY,1H−13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines. © 1991, American Chemical Society. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026083261&origin=inward http://repository.li.mahidol.ac.th/dspace/handle/123456789/22012 |
ISSN: | 15206025 01633864 |
Appears in Collections: | Scopus 1991-2000 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.