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|Title:||Plant anticancer agents, XLVIII. New cytotoxic flavonoids from muntingia calabura roots|
John M. Pezzuto
D. Doel Soejarto
A. Douglas Kinghorn
Norman R. Farnsworth
University of Illinois at Chicago
Thailand Royal Forest Department
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Natural Products. Vol.54, No.1 (1991), 196-206|
|Abstract:||From a cytotoxic Et2O soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1–7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1–12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on1H−1H COSY,1H−13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines. © 1991, American Chemical Society. All rights reserved.|
|Appears in Collections:||Scopus 1991-2000|
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