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Title: Plant anticancer agents, XLVIII. New cytotoxic flavonoids from muntingia calabura roots
Authors: Norito Kaneda
John M. Pezzuto
D. Doel Soejarto
A. Douglas Kinghorn
Norman R. Farnsworth
Thawatchai Santisuk
Patoomratana Tuchinda
Jinda Udchachon
Vichai Reutrakul
University of Illinois at Chicago
Thailand Royal Forest Department
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1991
Citation: Journal of Natural Products. Vol.54, No.1 (1991), 196-206
Abstract: From a cytotoxic Et2O soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1–7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1–12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on1H−1H COSY,1H−13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines. © 1991, American Chemical Society. All rights reserved.
ISSN: 15206025
Appears in Collections:Scopus 1991-2000

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