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Title: Diagnosis of melioidosis by means of an ELISA detecting antibodies to Pseudomonas pseudomallei exotoxin. Preliminary assay evaluation
Authors: C. J. Smith
M. Jones
D. A.B. Dance
W. Chaowagul
N. J. White
Faculty of Science and Innovation
Mahidol University
John Radcliffe Hospital
Sappasitthiprasong Hospital
London School of Hygiene & Tropical Medicine
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Jan-1991
Citation: World Journal of Microbiology and Biotechnology. Vol.7, No.1 (1991), 29-36
Abstract: An ELISA system for the detection of human antibodies to Pseudomonas pseudomallei exotoxin is described. Analysis of control sera and sera from patients with culture-positive melioidosis showed that both IgG and IgM antibodies to exotoxin were detectable in patients with melioidosis. This implies that the exotoxin is produced in vivo by P. pseudomallei, and may be involved in the pathogenesis of melioidosis. Furthermore, these rapid and simple assays may prove to be useful for the serodiagnosis of the disease. © 1991, Rapid Communications of Oxford Ltd. All rights reserved.
ISSN: 15730972
Appears in Collections:Scopus 1991-2000

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