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Title: Rosette formation by Plasmodium coatneyi-infected red blood cells
Authors: R. Udomsangpetch
A. E. Brown
C. D. Smith
H. K. Webster
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1991
Citation: American Journal of Tropical Medicine and Hygiene. Vol.44, No.4 (1991), 399-401
Abstract: Animal models are needed for the study of cytoadherence in falciparum malaria. Red blood cell (RBC) rosette formation is one type of cytoadherence and appears to be associated with knob formation, endothelial cell adhesion and sequestration of Plasmodium-infected RBCs. Since Plasmodium coatneyi-infected RBCs develop knobs and sequester, we hypothesized that they also form rosettes. RBCs from P. coatneyi-infected rhesus monkeys (Macaca-mulatta) were collected, allowed to mature overnight in vitro and found to form rosettes as hypothesized. This observation adds to the known falciparum-like characteristics of P. coatneyi, and suggests that the Macaca mulatta-P. coatneyi model may be appropriate for pathophysiologic studies of cytoadherence.
ISSN: 00029637
Appears in Collections:Scopus 1991-2000

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