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Title: Intracranial pressure in childhood cerebral malaria
Authors: D. Waller
J. Crawley
F. Nosten
D. Chapman
S. Krishna
C. Craddock
D. Brewster
N. J. White
Mahidol University
Nuffield Department of Clinical Medicine
Royal Victoria Teaching Hospital Gambia
Medical Research Council Laboratories Gambia
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1991
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.85, No.3 (1991), 362-364
Abstract: Lumbar punctures were performed in 40 Gambian children with acute cerebral malaria aged between 18 months and 10 years. The mean opening pressure was elevated in 32 (80%) of the children, but was not significantly different in the 14 fatal cases compared with survivors: 110 (standard deviation 71) versus 131 (58) mm of cerebrospinal fluid respectively. Cerebral perfusion pressures were also similar in the 2 groups: 64 (20) mm Hg versus 64 (11) mm Hg respectively. There was no clear clinical evidence of raised intracranial pressure, and no evidence of deterioration immediately following lumbar puncture. Nevertheless brain swelling, and consequent brain-stem compression, may contribute to a fatal outcome in cerebral malaria-particularly in those children who die from sudden respiratory arrest. A prospective evaluation of osmotic agents in childhood cerebral malaria seems to be justified. © 1991.
ISSN: 00359203
Appears in Collections:Scopus 1991-2000

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