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Title: Prolonged QT interval and risk of sudden death in South-East Asian men
Authors: R. G. Munger
M. P. Jones
R. J. Prineas
R. S. Crow
S. Changbumrung
V. Wangsuphachart
V. Keane
University of Iowa Carver College of Medicine
University of Miami Leonard M. Miller School of Medicine
University of Minnesota School of Public Health
Mahidol University
Organisation internationale pour les migrations
Keywords: Medicine
Issue Date: 3-Aug-1991
Citation: The Lancet. Vol.338, No.8762 (1991), 280-281
Abstract: Sudden death in sleep occurs in substantial numbers among young men in South-East Asia. The frequencies of electrocardiographic abnormalities were measured in groups with varying risks of such sudden death. The mean heart-rate-corrected QT interval (QTc) was significantly (p<0·05) greater among 123 Laotian refugees in Thailand at high risk (405 [95% confidence interval 397-413] ms) than in 77 Laotian refugees in the United States at lower risk (364 [359-369] ms) and 199 non-Asian US residents at negligible risk (358 [354-362] ms). Among refugees in Thailand, prolonged QTc interval was associated with poor thiamine status and a history of seizure-like episodes in sleep. Thiamine deficiency may be a cause of prolonged QT interval and sudden death in this region. © 1991.
ISSN: 01406736
Appears in Collections:Scopus 1991-2000

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