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dc.contributor.authorW. Supanaranonden_US
dc.contributor.authorT. M E Davisen_US
dc.contributor.authorS. Pukrittayakameeen_US
dc.contributor.authorK. Silamuten_US
dc.contributor.authorJ. Karbwangen_US
dc.contributor.authorP. Moluntoen_US
dc.contributor.authorL. Chanonden_US
dc.contributor.authorN. J. Whiteen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherJohn Radcliffe Hospitalen_US
dc.contributor.otherPaholpolpayuhasena Hospitalen_US
dc.identifier.citationEuropean Journal of Clinical Pharmacology. Vol.40, No.1 (1991), 49-52en_US
dc.description.abstractPlasma quinine concentrations following oral quinine sulphate 10 mg salt/kg have been measured by HPLC in 15 adult Thai patients with uncomplicated falciparum malaria. In 10 of the same patients the study was repeated in convalescence. In acute malaria plasma concentrations were approximately 50% higher than in convalescence; the mean acute peak plasma quinine concentration was 8.4 mg·l-1 compared to 5.7 mg·l-1 in convalescence. There was considerable variation in the rate of drug absorption, particularly in acute malaria. The mean time to peak plasma concentration was 5.9 h in acute malaria and 3.2 h in convalescence. The apparent clearance of oral quinine (CL/f) during the illness was 1.51 ml·kg-1·min-1, which was significantly lower than in convalescence - 2.67 ml·kg-·min-1. Estimated free quinine clearance was also lower in the acute phase: 30.6 compared to 49.0 ml·kg-1·min-1 in convalescence. Mean (SD) plasma protein binding of quinine was 94.7% in acute malaria and 92.8% in convalescence. Binding was significantly correlated with the plasma concentration of α1 acid glycoprotein (r=0.5), which was significantly higher in the acute phase; 1.48 g·l-1 compared to 1.05 g·l-1 during convalescence. Oral quinine sulphate was well absorbed in uncomplicated falciparum malaria. High blood concentrations following the administration of oral quinine in acute malaria are probably related to increased plasma protein binding, lower apparent volume of distribution, and a reduction in its systemic clearance. © 1991 Springer-Verlag.en_US
dc.rightsMahidol Universityen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleDisposition of oral quinine in acute falciparum malariaen_US
Appears in Collections:Scopus 1991-2000

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