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|Title:||Plant anticancer agents, l. cytotoxic triterpenes from sandoricum koetjape stems|
John M. Pezzuto
Norman R. Farnsworth
University of Illinois at Chicago
Thailand Royal Forest Department
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Natural Products. Vol.55, No.5 (1992), 654-659|
|Abstract:||A new ring-A secotriterpene, koetjapic acid , and five known compounds, 3-oxo-olean-12-en-29-oic acid  (a novel natural product), katonic acid , (−)-alloaromadendrene, (−)-caryophyllene oxide, and (+)-spathulenol, have been isolated and characterized from a cytotoxic Et2O-soluble extract of Sandoricum koetjape stems. Of these compounds, 2 and 3 demonstrated significant cytotoxic activity against cultured P-388 cells (ED50values of 0.61 and 0.11 μg/ml, respectively). Significant, albeit less intense, cytotoxicity was also observed with a variety of cultured human cancer cells. The13C-nmr chemical shifts of these triterpenes were assigned unambiguously using selective INEPT nmr experiments. Aside from compounds 2 and 3, these substances were not toxic with cultured cells. © 1992, American Chemical Society. All rights reserved.|
|Appears in Collections:||Scopus 1991-2000|
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