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Title: Repeated exposure to opisthorchis viverrini and treatment with the antihelminthic praziquantel lacks carcinogenic potential
Authors: Witaya Thamavit
Malcolm A. Moore
Somsak Ruchirawat
Nobuyuki Ito
Mahidol University
Nagoya City University Medical School
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Feb-1992
Citation: Carcinogenesis. Vol.13, No.2 (1992), 309-311
Abstract: The effects of repeated Praziquantel administration, subsequent to infection and reinfection w Opisthorchis viverrini (OV), on lesion development in the Syrian hamster liver were investigated. Five applications of the antihelminthic drag were made (300 mg/kg body wt, i.g.), each time ∼5 weeks after dosing with 60-80 OV metacercarine at weeks 0, 8, 16, 24 and 32. The animals were then maintained until week 40 when they were killed; histopathological investigation revealed no significant development of either hepatocellular of cholangiocellular preneoplastic/neoplastic lesions. The results indicate that repeated exposure to Praziquantel at levels sufficient for successful removal of parasite infestation does not itself carry carcinogenic risk. © 1992 Oxford University Press.
ISSN: 01433334
Appears in Collections:Scopus 1991-2000

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