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Title: Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver
Authors: W. Thamavit
M. A. Moore
Somsak Ruchirawat
N. Ito
Mahidol University
Nagoya City University Medical School
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 31-Jan-1992
Citation: Cancer Letters. Vol.61, No.3 (1992), 229-232
Abstract: The effects of repeated praziquantel administration subsequent to dimethylnitrosamine (DMN) treatment of Syrian hamsters were investigated. The antihelminthic drug was given (200 mg/kg body wt. as a suspension in corn oil, by i.g. intubation) 11 times at 2 week intervals starting at week 4 after initial 20 mg/kg DMN i.p: injections at weeks 0 and 2. Sacrifice at week 28 revealed no differences in either hepatocellular or cholangiocellular lesion development between carcinogen-initiated groups with or without antihelminthic treatment. No lesions were observed in the praziquantel alone or untreated groups. The results thus indicate no promotion potential for praziquantel on nitrosamine-induced lesions in the hamster liver. © 1992.
ISSN: 03043835
Appears in Collections:Scopus 1991-2000

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