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|Title:||Lack of modulation effects of praziquantel on DMN-induced lesion development in the Syrian hamster liver|
M. A. Moore
Nagoya City University Medical School
|Keywords:||Biochemistry, Genetics and Molecular Biology;Medicine|
|Citation:||Cancer Letters. Vol.61, No.3 (1992), 229-232|
|Abstract:||The effects of repeated praziquantel administration subsequent to dimethylnitrosamine (DMN) treatment of Syrian hamsters were investigated. The antihelminthic drug was given (200 mg/kg body wt. as a suspension in corn oil, by i.g. intubation) 11 times at 2 week intervals starting at week 4 after initial 20 mg/kg DMN i.p: injections at weeks 0 and 2. Sacrifice at week 28 revealed no differences in either hepatocellular or cholangiocellular lesion development between carcinogen-initiated groups with or without antihelminthic treatment. No lesions were observed in the praziquantel alone or untreated groups. The results thus indicate no promotion potential for praziquantel on nitrosamine-induced lesions in the hamster liver. © 1992.|
|Appears in Collections:||Scopus 1991-2000|
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