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Title: Studies on a new antimalarial compound: Pyronaridine
Authors: Chen Chang
Tang Lin-Hua
Chun Jantanavivat
Chinese Center for Disease Control and Prevention
Mahidol University
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Jan-1992
Citation: Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.86, No.1 (1992), 7-10
Abstract: Pyronaridine, a hydroxyanilino-benzonaphthyridine derivative synthesized in 1970, is a new antimalarial compound which has been in use in China for more than 10 years. The drug is highly effective against Plasmodium falciparum and P. vivax. Furthermore, it is efficacious in combatting chloroquine-resistant strains of falciparum malaria both in vitro and in vivo, in human patients. Extensive field studies involving several thousand cases have shown that pyronaridine has promising therapeutic value in the treatment of malarial infection, including chloroquine-resistant infections. Pyronaridine given orally, intramuscularly or by intravenous drip is not only effective against malaria but also has low toxicity. © Oxford University Press.
ISSN: 18783503
Appears in Collections:Scopus 1991-2000

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