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Title: Comparison of oral artemether and mefloquine in acute uncomplicated falciparum malaria
Authors: J. Karbwang
K. Na Bangchang
A. Thanavibul
D. Bunnag
T. Chongsuphajaisiddhi
T. Harinasuta
Mahidol University
Keywords: Medicine
Issue Date: 21-Nov-1992
Citation: The Lancet. Vol.340, No.8830 (1992), 1245-1248
Abstract: Plasmodium falciparum malaria in Thailand is highly resistant to available antimalarials, and alternative drugs are needed urgently. Artemether is effective against falciparum malaria but associated with a high recrudescence rate. The proper dosage regimen remains to be defined. We have done a clinical trial comparing mefloquine 1250 mg in divided doses with oral artemether at 700 mg total dose given over 5 days in acute uncomplicated falciparum malaria. 46 patients, admitted to the Bangkok Hospital for Tropical Diseases, were randomised to receive either mefloquine (12) or artemether (34). Hospital follow-up was 28 days for the artemether group and 42 days for the mefloquine group. Oral artemether gave a significantly faster parasite clearance time than mefloquine (30 vs 64 h), and a significantly better cure rate (97 vs 64%) with fewer episodes of dizziness and vomiting. Oral artemether at 700 mg given over 5 days is effective and well tolerated. The cure rate with this regimen is higher than that reported by previous studies with 600 mg intramuscular artemether given over 5 days. Oral artemether can be considered as an alternative drug for multiple-drug-resistant falciparum malaria. © 1992.
ISSN: 01406736
Appears in Collections:Scopus 1991-2000

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