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Title: Pharmacokinetics of mefloquine in children aged 6 to 24 months
Authors: V. Singhasivanon
T. Chongsuphajaisiddhi
A. Sabcharoen
P. Attanath
H. K. Webster
W. H. Wernsdorfer
U. K. Sheth
I. Djaja Lika
Mahidol University
Armed Forces Research Institute of Medical Sciences, Thailand
Organisation Mondiale de la Sante
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Oct-1992
Citation: European Journal of Drug Metabolism and Pharmacokinetics. Vol.17, No.4 (1992), 275-279
Abstract: The study was carried out in 12 children aged 6 months to 2 years, with uncomplicated falciparum malaria admitted to the Hospital for Tropical Diseases, Bangkok. They were treated with mefloquine in the form of MSP (mefloquine 2S0 mg+sulfadoxine 500 mg +pyrimethamine 25 mg) at a single dose of 25 mg mefloquine base/kg body weight All of them were cured (28 days follow-up) with minimal side effects. Pharmacokinetic parameter determination was carried out in 9 cases. The results revealed that MRT, t1/2 and tmax in this study (children 6-24 months old) are comparable to the values in children aged 5-12 years, but shorter than in adult patients. Cmax and AUC in children 6-24 months old are comparable to those in children of 5-12 years, but much higher than in adult patients. Vz/f values in this study are comparable to those in children 5-12 years old, but lower than in adult patients. © 1992 Springer-Verlag.
ISSN: 21070180
Appears in Collections:Scopus 1991-2000

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