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Title: Histomorphological Characteristics of Cholangiocellular Carcinomas in Northeast Thailand, Where a Region Infection with the Liver Fluke, Opisthorchis viverrini is Endemic
Authors: Tomoyuki Shirai
Chawalit Pairojkul
Kumiko Ogawa
Hatsumi Naito
Witaya Thamavit
Watcharabhong Bhudhisawat
Nobuyuki Ito
Neurosurgery City University
Khon Kaen University
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-1992
Citation: Pathology International. Vol.42, No.10 (1992), 734-739
Abstract: Northeast Thailand has a very high incidence rate of intrahepatic biliary tumors which is believed to closely related to infestation with the liver fluke, Opisthorchis viverrini. This study was conducted to ascertain whether there are any phenotypic differences in such tumors between northeast Thailand and Japan, a country free of liver flukes. Forty one intrahepatic cholangiocarcinomas from patients in northeast Thailand were histopathologically compared with 39 lesions collected in Japan. The proportions of each type of adenocarcinoma in the Thailand cases were similar to those of the Japanese cases except that medullary type poorly differentiated tubular adenocarcinoma was only found in the series from Thailand. Whether the presence of medullary lesions only in the cases from the area of endemic fluke infection implies differences in etiology remains in question. The similarity in the majority of histological types, the inflammatory reactions observed in the bile ducts and the earlier development of tumors in association with parasites suggests that tumor promotion resulting from liver fluke infection rather than quantitative or qualitative differences in genetic alterations is responsible for the high frequency of cholangiocellular carcinomas in northeast Thailand. Acta Pathol Jpn 42: 734–739, 1992. Copyright © 1992, Wiley Blackwell. All rights reserved
ISSN: 14401827
Appears in Collections:Scopus 1991-2000

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