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|Title:||Safety and immunogenicity of different immunization regimens of cvd 103-hgr live oral cholera vaccine in soldiers and civilians in thailand|
David N. Taylor
Yu Leung Lim
James B. Kaper
Steven S. Wasserman
Myron M. Levine
Walter Reed Army Institute of Research
University of Maryland School of Medicine
Berna Biotech AG
|Citation:||Journal of Infectious Diseases. Vol.165, No.6 (1992), 1042-1048|
|Abstract:||Attenuated Vibrio cholerae oral vaccine CVD 103-HgR was well tolerated by 324 Thai soldiers and civilians. Most received a single 5 × 10(r) cfu dose, while 40 each received one or two 5 × 109cfu doses. Vibriocidal antibody (the best correlate of immunity) seroconversion was lower in soldiers than civilians (P <.001). Increasing the vaccine dose to 5 × 109cfu raised the geometric mean titer (P <.001). A second 5 × 109cfu dose one week later did not notably increase serocon- versions. Likelihood of seroconversion was inversely correlated with baseline vibriocidal titer (P <.001). CVD 103-HgR caused seroconversion in most subjects with baseline titers <1:40, including 100% of civilians after one 5 × 10(r) cfu dose, 79% of soldiers after one 5 × 109cfu dose, and 45% of soldiers after one 5 × 10scfu dose. In persons with elevated baseline titers, vibriocidal antibody seroconversion is not a sensitive measure of whether vaccine has boosted intestinal immunity; for such subjects, other measurements must be used. Study regimens in endemic areas should use a single 5 × 109cfu dose. © 1992 The University of Chicago.|
|Appears in Collections:||Scopus 1991-2000|
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