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Title: Safety and immunogenicity of different immunization regimens of cvd 103-hgr live oral cholera vaccine in soldiers and civilians in thailand
Authors: Pisit Su-Arehawaratana
Preecha Singharaj
David N. Taylor
Charles Hoge
Andrew Trofa
Krit Kuvanont
Sricharoen Migasena
Punnee Pitisuttitham
Yu Leung Lim
Genevieve Losonsky
James B. Kaper
Steven S. Wasserman
Stanley Cryz
Peter Echeverria
Myron M. Levine
Mahidol University
Walter Reed Army Institute of Research
University of Maryland School of Medicine
Berna Biotech AG
Keywords: Medicine
Issue Date: 1-Jan-1992
Citation: Journal of Infectious Diseases. Vol.165, No.6 (1992), 1042-1048
Abstract: Attenuated Vibrio cholerae oral vaccine CVD 103-HgR was well tolerated by 324 Thai soldiers and civilians. Most received a single 5 × 10(r) cfu dose, while 40 each received one or two 5 × 109cfu doses. Vibriocidal antibody (the best correlate of immunity) seroconversion was lower in soldiers than civilians (P <.001). Increasing the vaccine dose to 5 × 109cfu raised the geometric mean titer (P <.001). A second 5 × 109cfu dose one week later did not notably increase serocon- versions. Likelihood of seroconversion was inversely correlated with baseline vibriocidal titer (P <.001). CVD 103-HgR caused seroconversion in most subjects with baseline titers <1:40, including 100% of civilians after one 5 × 10(r) cfu dose, 79% of soldiers after one 5 × 109cfu dose, and 45% of soldiers after one 5 × 10scfu dose. In persons with elevated baseline titers, vibriocidal antibody seroconversion is not a sensitive measure of whether vaccine has boosted intestinal immunity; for such subjects, other measurements must be used. Study regimens in endemic areas should use a single 5 × 109cfu dose. © 1992 The University of Chicago.
ISSN: 15376613
Appears in Collections:Scopus 1991-2000

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