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Title: Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza
Authors: P. Claeson
A. Panthong
P. Tuchinda
V. Reutrakul
D. Kanjanapothi
W. C. Taylor
T. Santisuk
Mahidol University
Keywords: Agricultural and Biological Sciences;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 2-Nov-1993
Citation: Planta Medica. Vol.59, No.5 (1993), 451-454
Abstract: Bioassay-guided fractionation of a hexane extract of the rhizomes of Curcuma xanthorrhiza Roxb. (Zingiberaceae) led to the isolation of three non-phenolic diarylheptanoids, identified mainly by high-field 1H-NMR as trans-trans-1,7-diphenyl-1,3-heptadien-4-one (alnustone), trans-1,7-diphenyl-1-hepten-5-ol, and trans,trans-1,7-diphenyl-1,3-heptadien-5-ol. The latter is reported for the first time as a plant constituent. Germacrone, curzerenone, and cinnamaldehyde were also isolated and identified. The three diarylheptanoids all exerted significant anti-inflammatory activity in the assay of carrageenin-induced hind paw edema in rats.
ISSN: 00320943
Appears in Collections:Scopus 1991-2000

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