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Title: Acute effect and mechanism of action of prolactin on the in situ passive calcium absorption in rat
Authors: Nateetip Krishnamra
Sutada Lotinun
Liangchai Limlomwongse
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-1993
Citation: Bone and Mineral. Vol.23, No.3 (1993), 253-266
Abstract: Acute effect of prolactin (PRL) given intraperitoneally 1 h before on calcium fluxes was studied in 6 in situ intestinal segments from weaned, sexually mature and aged rats. In mature rats, PRL increased net passive calcium absorption in jejunum and cecum by 64% and 38%, respectively, by enhancing lumen-to-plasma calcium flux (CaL-P) in the jejunum and by reducing plasma-to-lumen flux (CaP-L) in the cecum. Since PRL-enhanced both CaL-Pand CaP-Lin the ileum, net calcium absorption did not change. In weaned rats, PRL significantly increased CaL-Pin the jejunum but not in the ileum. However, the increase in net absorption was not significant. In contrast, effect of PRL was not seen in aged rats. By demonstrating an absence of PRL action on jejunal calcium fluxes when sodium-free test solution was used, we reconfirmed the sodium-dependent PRL action on passive calcium absorption. The PRL-induced parallel increase in the lumen-to-plasma transport of45Ca and [3H]mannitol indicated that PRL action was to increase the paracellular transport of calcium. © 1993, Elsevier Scientific Publishers Ireland Ltd. All rights reserved. All rights reserved.
ISSN: 01696009
Appears in Collections:Scopus 1991-2000

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