Please use this identifier to cite or link to this item:
|Title:||<sup>1</sup> H- and <sup>13</sup>C-NMR assignments of phyllanthin and hypophyllanthin: Lignans that enhance cytotoxic responses with cultured multidrug-resistant cells|
Hui Ling Shieh
John M. Pezzuto
Geoffrey A. Cordell
University of Illinois at Chicago
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Natural Products. Vol.56, No.2 (1993), 233-239|
|Abstract:||Complete 1H-nmr data and unambiguous assignments of the 13C-nmr spectra of phyllanthin  and hypophyllanthin  were obtained through extensive nmr studies, including homonuclear COSY, homonuclear decoupling, APT, HETCOR, nOe difference, selective INEPT, and COLOC experiments. The absolute configuration of hypophyllanthin  was determined by cd. Neither of these lignans demonstrated significant cytotoxic activity when evaluated with a battery of cultured mammalian cells, but both were found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB cells. In addition, 1 was found to displace the binding of vinblastine with membrane vesicles derived from this cell line, suggesting an interaction with the P-glycoprotein. © 1993, American Chemical Society. All rights reserved.|
|Appears in Collections:||Scopus 1991-2000|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.