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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/22554
Title: <sup>1</sup> H- and <sup>13</sup>C-NMR assignments of phyllanthin and hypophyllanthin: Lignans that enhance cytotoxic responses with cultured multidrug-resistant cells
Authors: Aimon Somanabandhu
Siriporn Nitayangkura
Chulabhorn Mahidol
Somsak Ruchirawat
Kittisak Likhitwitayawuid
Hui Ling Shieh
Heebyung Chai
John M. Pezzuto
Geoffrey A. Cordell
Mahidol University
University of Illinois at Chicago
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1993
Citation: Journal of Natural Products. Vol.56, No.2 (1993), 233-239
Abstract: Complete 1H-nmr data and unambiguous assignments of the 13C-nmr spectra of phyllanthin [1] and hypophyllanthin [2] were obtained through extensive nmr studies, including homonuclear COSY, homonuclear decoupling, APT, HETCOR, nOe difference, selective INEPT, and COLOC experiments. The absolute configuration of hypophyllanthin [2] was determined by cd. Neither of these lignans demonstrated significant cytotoxic activity when evaluated with a battery of cultured mammalian cells, but both were found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB cells. In addition, 1 was found to displace the binding of vinblastine with membrane vesicles derived from this cell line, suggesting an interaction with the P-glycoprotein. © 1993, American Chemical Society. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0027551488&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/22554
ISSN: 15206025
01633864
Appears in Collections:Scopus 1991-2000

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