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dc.contributor.authorAimon Somanabandhuen_US
dc.contributor.authorSiriporn Nitayangkuraen_US
dc.contributor.authorChulabhorn Mahidolen_US
dc.contributor.authorSomsak Ruchirawaten_US
dc.contributor.authorKittisak Likhitwitayawuiden_US
dc.contributor.authorHui Ling Shiehen_US
dc.contributor.authorHeebyung Chaien_US
dc.contributor.authorJohn M. Pezzutoen_US
dc.contributor.authorGeoffrey A. Cordellen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Illinois at Chicagoen_US
dc.identifier.citationJournal of Natural Products. Vol.56, No.2 (1993), 233-239en_US
dc.description.abstractComplete 1H-nmr data and unambiguous assignments of the 13C-nmr spectra of phyllanthin [1] and hypophyllanthin [2] were obtained through extensive nmr studies, including homonuclear COSY, homonuclear decoupling, APT, HETCOR, nOe difference, selective INEPT, and COLOC experiments. The absolute configuration of hypophyllanthin [2] was determined by cd. Neither of these lignans demonstrated significant cytotoxic activity when evaluated with a battery of cultured mammalian cells, but both were found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB cells. In addition, 1 was found to displace the binding of vinblastine with membrane vesicles derived from this cell line, suggesting an interaction with the P-glycoprotein. © 1993, American Chemical Society. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.title<sup>1</sup> H- and <sup>13</sup>C-NMR assignments of phyllanthin and hypophyllanthin: Lignans that enhance cytotoxic responses with cultured multidrug-resistant cellsen_US
Appears in Collections:Scopus 1991-2000

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