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Title: Invasive squamous‐cell cervical carcinoma and combined oral contraceptives: Results from a multinational study
Authors: Geoffrey Berry
Robert Maclennan
Rodney Shearman
Tatiana Jelihovsky
Joan Cooper Booth
Ramiro Molina
Luis Martinez
Oriana Salas
Alfredo Dabancens
Chen Zhiheng
Tao Yun
Hu Yong Wei
Alvaro Cuadros
Nubia Aristizabal
Baruch Modan
Elaine Ron
Esther Alfandary
J. G. Mati
Patrick Kenya
Alfred Kungu
D. Gatei
Hector Rodriguez Cuevas
Socorro Benavides Salazar
Antonio Palet
Patricia Ontiveros
Pat A. Ibeziako
T. A. Junaid
P. Aghediuno
A. A. Abioye
Ruben A. Apelo
Julietta R. De la Cruz
Jose Baens
Benjamin D. Canlas
Suporn Silpisornkosol
Tieng Pardthaisong
Viruch Charoeniam
Choti Theetranont
Banpot Boosiri
Supawat Chutivongse
Pramuan Virutamasen
Chansuda Wongsrichanalai
Sermsri Sindhavananda
Suporn Koetsawang
Duangdao Rachawat
Amorn Koetsawang
Gustave Riotton
William M. Christopherson
Joseph L. Melnick
Ervin Adam
David B. Thomas
Roberta M. Ray
Elizabeth A. Noonan
Janet L. Stanford
Karin A. Rosenblatt
Susan Holck
Olav Meirik
Timothy M.M. Farley
David B. Thomas
Roberta M. Ray
The University of Sydney
Hospital Jose Joaquin Aguirre
Shanghai Institute of Planned Parenthood Research
Hospital Universitario
Chaim Sheba Medical Center Israel
University of Nairobi
Hospital General de Mexico
University of Ibadan
University of the Philippines Manila
Chiang Mai University
Chulalongkorn University
Mahidol University
Universite de Geneve Faculte de Medecine
University of Louisville Health Sciences Center
Baylor College of Medicine
Fred Hutchinson Cancer Research Center
Organisation Mondiale de la Sante
Hospital del Salvador
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jan-1993
Citation: International Journal of Cancer. Vol.55, No.2 (1993), 228-236
Abstract: Data from a hospital‐based case‐control study collected in 11 participating centers in 9 countries were analyzed to determine whether use of combined oral contraceptives alters risk of invasive squamous‐cell cervical cancer. Information on prior use of oral contraceptives, screening for cervical cancer, and suspected risk factors for this disease were ascertained from interviews of 2361 cases and 13,644 controls. A history of smoking and anal and genital warts was obtained, and blood specimens were collected for measurement of antibodies against herpes simplex and cytomegalo viruses, from selected sub‐sets of these women, as was a sexual history from interviews of husbands. The relative risk of invasive squamous‐cell cervical carcinoma was estimated to be 1.31, with a 95% confidence interval that excluded one, in women who ever used combined oral contraceptives. Risk of this disease increased significantly with duration of use after 4 to 5 years from first exposure, and declined with the passage of time after cessation of use to that of non‐users in about 8 years. No sources of bias or confounding were identified that offered plausible explanations for these findings. The strength of these results, and their consistency with those from other studies, suggest that a causal relationship may exist between use of combined oral contraceptives and squamous‐cell cervical carcinoma. Women who have used these products for 4 or more years, and who most recently used them within the past 8 years, should receive high priority for cervical cytologic screening. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
ISSN: 10970215
Appears in Collections:Scopus 1991-2000

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