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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/22728
Title: Cardiac effects of antimalarial treatment with halofantrine
Authors: F. Nosten
F. O. ter Kuile
C. Luxemburger
C. Woodrow
T. Chongsuphajaisiddhi
N. J. White
D. E. Kyle
Shoklo Malaria Research Unit
Mahidol University
Academic Medical Centre, University of Amsterdam
Armed Forces Research Institute of Medical Sciences, Thailand
John Radcliffe Hospital
Keywords: Medicine
Issue Date: 24-Apr-1993
Citation: The Lancet. Vol.341, No.8852 (1993), 1054-1056
Abstract: In a prospective electrocardiographic study of Karen patients with acute uncomplicated falciparum malaria, mefloquine (25 mg/kg) had no cardiac effects (n=53), but halofantrine (72 mg/kg) induced consistent dose-related lengthening of the PR and QT intervals in all 61 patients treated. The likelihood of significant QTc prolongation (by more than 25% or a QTc of 0·55 s1/2or more) was greater after halofantrine as retreatment following mefloquine failure than as primary treatment (7/10 vs 18/51; relative risk 2·0 [95% Cl 1·1-3·4], p = 0·04). More than 60% of the effect occurred with three doses of halofantrine (24 mg/kg). The arrhythmogenic potential of halofantrine should now be investigated. © 1993.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0027404778&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/22728
ISSN: 01406736
Appears in Collections:Scopus 1991-2000

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