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Title: Immunoproliferative small intestinal disease (IPSID) in Thailand
Authors: C. Pramoolsinsap
S. Kurathong
V. Atichartakarn
P. Nitiyanand
Mahidol University
Keywords: Medicine
Issue Date: 1-Jan-1993
Citation: Southeast Asian Journal of Tropical Medicine and Public Health. Vol.24, No.1 (1993), 11-17
Abstract: Immunoproliferative small intestinal disease (IPSID) is prevalent in the Mediterranean region and in many Thirld World countries but is rare in Southeast Asia. Between 1980-1990, 4 cases of IPSID were admitted to Ramathibodi Hospital, Bangkok. Three were males and the mean age was 32 ± 20.2 years. All patients presented with chronic diarrhea of 7 months to 6 yuears duration, and weight loss of 15 to 31 kg. All were malnourished, three cachectic, and one patient showed growth retardation. Intestinal parasites were found in all cases: two had multiple infections and three had uncommon protozoal infections (coccidium, cryptosporidium). Barium radiographs revealed intestinal mucosa fold thickening with malabsorption pattern in all cases. Alpha chain IgA was detected in one patient. The remainder underwent exploratory laparotomy and the histological finding was of plasmalymphocytic infiltration of the small intestinal mucosa. All patients responded to oral tetracycline with complete remission occurring in one case. During the follow-up period, 3 cases had progressive retractable clinical courses but all died 2 to 5 years after the diagnosis. The causes of death in these patients were secondary bacterial infection (1 case), intestinal tuberculosis (1 case), fungal infection (1 case) and immunoblastic sarcoma in another case. The results of this study confirm the occurrence of IPSID in Thailand. IPSID responds to oral antibiotic therapy and complete remission may be achieved during the early reversible benign phase, thus an awareness of its occurrence is of clinical importance.
ISSN: 00383619
Appears in Collections:Scopus 1991-2000

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