Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/22802
Title: Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria
Authors: S. KRISHNA
F. Ter KUILE
W. SUPANARANOND
S. PUKRITTAYAKAMEE
P. TEJA‐ISAVADHARM
D. KYLE
N. J. WHITE
Mahidol University
John Radcliffe Hospital
Academic Medical Centre, University of Amsterdam
The Armed Forces Pharmaceutical Factory
Keywords: Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-1993
Citation: British Journal of Clinical Pharmacology. Vol.36, No.6 (1993), 585-591
Abstract: The pharmacokinetics, efficacy and toxicity of a new parenteral formulation of halofantrine hydrochloride were evaluated in 12 adults with acute uncomplicated falciparum malaria and nine adults who attended in convalescence. Intravenous halofantrine (1 mg kg−1infused in 1 h) was given every 8 h for a total of three doses in the acute study. Halofantrine cleared parasitaemia rapidly in all but one patient, with a mean (s.d.) parasite clearance time of 71 (29) h. Convalescent patients received a single infusion (1 mg kg−1in 1 h). An open two‐compartment model with the following parameters described the pharmacokinetics of halofantrine in acute malaria (mean (s.d)): V1= 0.36 (0.18) 1 kg−1; CL = 0.355 (0.18) 1 h−1kg−1; t1/2;α= 0.19 (0.12) h; t1/2;β= 14.4 (7.5) h. Intravenous halofantrine in acute malaria produced significant prolongations of the QT and QTcintervals (mean (s.d.)) of 20 (15%) and 8.2 (5.6)%, respectively (P < 0.001) after the third dose, but no clinically significant cardiotoxcity. Eight patients experienced mild to moderate thrombophlebitis at the halofantrine infusion site which had resolved in six by the time of follow‐up. In the single treatment failure who received oral quinine, there was a large rise in plasma halofantrine concentration but this did not result in detectable toxicity. These data provide the basis for the design of improved dosing regimens for the use of parenteral halofantrine in malaria. 1993 The British Pharmacological Society
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0027137381&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/22802
ISSN: 13652125
03065251
Appears in Collections:Scopus 1991-2000

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.