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Title: Antimalarial activity of biflavonoids from Ochna integerrima
Authors: Chikara Ichino
Hiroaki Kiyohara
Noppamas Soonthornchareonnon
Wongsatit Chuakul
Aki Ishiyama
Hitomi Sekiguchi
Miyuki Namatame
Kazuhiko Otoguro
Satoshi Omura
Haruki Yamada
Kitasato University
The Kitasato Institute
Mahidol University
Keywords: Agricultural and Biological Sciences;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2006
Citation: Planta Medica. Vol.72, No.7 (2006), 611-614
Abstract: During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 μg/mL) whereas extracts from the inner barks of O. integerrima showed no antimalarial activity. Biflavanone (1), which had not been found previously from a natural plant source, was isolated as a potent antimalarial active ingredient (IC50 value: 80 ng/mL) from the extract of the outer barks. The stereoisomer of 1 (= compound 2) was also isolated from this plant; however, its activity was significantly lower than that of 1. © Georg Thieme Verlag KG Stuttgart.
ISSN: 00320943
Appears in Collections:Scopus 2006-2010

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