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|Title:||Three distinct reactions of 3,4-dihydroisoquinolines with azlactones: Novel synthesis of imidazoloisoquinolin-3-ones, benzo[a]quinolizin-4-ones, and benzo[d]azocin-4-ones|
Chulabhorn Research Institute
The Institute of Science and Technology for Research and Development, Mahidol University
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry|
|Citation:||Organic Letters. Vol.8, No.25 (2006), 5845-5848|
|Abstract:||(Diagram presented) A facile and direct synthetic entry to tricyclic imidazoloisoquinolin-3-ones and benzo[a]quinolizin-4-ones is reported based on the ring annulation of 1-unsubstituted and 1-substituted dihydroisoquinolines with azlactones under neutral conditions in a one-step procedure. Bicyclic 2,3-dihydrobenzo[djazocin-4-ones were also prepared using simple azlactone and 1-substituted dihydroisoquinolines in a one-pot reaction. © 2006 American Chemical Society.|
|Appears in Collections:||Scopus 2006-2010|
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