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Title: Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens
Authors: Vichai Reutrakul
Waraporn Chanakul
Manat Pohmakotr
Thaworn Jaipetch
Chalobon Yoosook
Jittra Kasisit
Chanita Napaswat
Thawatchai Santisuk
Samran Prabpai
Palangpon Kongsaeree
Patoomratana Tuchinda
Mahidol University
Thailand Royal Forest Department
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Dec-2006
Citation: Planta Medica. Vol.72, No.15 (2006), 1433-1435
Abstract: Two new xanthones, 1,3,8-trihydroxy-2,4-dimethoxyxanthone (1) and 1,7-dihydroxy-2,8-dimethoxyxanthone (2), along with twelve known compounds 3-14 were isolated from leaves and twigs of Cratoxylum arborescens. Compound 1, euxanthone (4), betulinic acid (8), lup-20(29)-ene-3β,30-diol (9), 3β-hydroxyl-up-20(29)-en-30-oic acid (10) and 3,4-dihydroxybenzoic acid (11) displayed anti-HIV-1 activities in the syncytium assay usingΔTat/RevMC99 virus and the 1A2 cell line system (EC50values between 3.9 and 32.2 μg/mL with TI ranging from 1.5 to 11.7), while 1,3,7-trihydroxy-6-methoxy-4,5-diisoprenylxanthone (3), 4, and 8-10 inhibited HIV-1 reverse transcriptase with IC50values between 8.7 and 84.9 μg/mL. © Georg Thieme Verlag KG Stuttgart.
ISSN: 00320943
Appears in Collections:Scopus 2006-2010

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