Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/22972
Title: Contrasting signatures of selection on the Plasmodium falciparum erythrocyte binding antigen gene family
Authors: Federica Verra
Watcharee Chokejindachai
Gareth D. Weedall
Spencer D. Polley
Tabitha W. Mwangi
Kevin Marsh
David J. Conway
London School of Hygiene & Tropical Medicine
Mahidol University
Centre for Geographic Medicine Research
Medical Research Council Laboratories Gambia
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Oct-2006
Citation: Molecular and Biochemical Parasitology. Vol.149, No.2 (2006), 182-190
Abstract: Erythrocyte binding antigens of Plasmodium falciparum are involved in erythrocyte invasion, and may be targets of acquired immunity. Of the five eba genes, protein products have been detected for eba-175, eba-181 and eba-140, but not for ψeba-165 or ebl-1, providing opportunity for comparative analysis of genetic variation to identify selection. Region II of each of these genes was sequenced from a cross-sectional sample of parasites in an endemic Kenyan population, and the frequency distributions of polymorphisms analysed. A positive value of Tajima's D was observed for eba-175 (D = 1.13) indicating an excess of intermediate frequency polymorphisms, while all other genes had negative values, the most negative being ebl-1 (D = -2.35) followed by ψeba-165 (D = -1.79). The eba-175 and ebl-1 genes were then studied in a sample of parasites from Thailand, for which a positive Tajima's D value was again observed for eba-175 (D = 1.79), and a negative value for ebl-1 (D = -1.85). This indicates that eba-175 is under balancing selection in each population, in strong contrast to the other members of the gene family, particularly ebl-1 and ψeba-165 that may have been under recent directional selection. Population expansion simulations were performed under a neutral model, further supporting the departures from neutrality of these genes. © 2006 Elsevier B.V. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748028816&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/22972
ISSN: 01666851
Appears in Collections:Scopus 2006-2010

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.