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dc.contributor.authorFederica Verraen_US
dc.contributor.authorWatcharee Chokejindachaien_US
dc.contributor.authorGareth D. Weedallen_US
dc.contributor.authorSpencer D. Polleyen_US
dc.contributor.authorTabitha W. Mwangien_US
dc.contributor.authorKevin Marshen_US
dc.contributor.authorDavid J. Conwayen_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCentre for Geographic Medicine Researchen_US
dc.contributor.otherMedical Research Council Laboratories Gambiaen_US
dc.date.accessioned2018-08-20T06:49:47Z-
dc.date.available2018-08-20T06:49:47Z-
dc.date.issued2006-10-01en_US
dc.identifier.citationMolecular and Biochemical Parasitology. Vol.149, No.2 (2006), 182-190en_US
dc.identifier.issn01666851en_US
dc.identifier.other2-s2.0-33748028816en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748028816&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/22972-
dc.description.abstractErythrocyte binding antigens of Plasmodium falciparum are involved in erythrocyte invasion, and may be targets of acquired immunity. Of the five eba genes, protein products have been detected for eba-175, eba-181 and eba-140, but not for ψeba-165 or ebl-1, providing opportunity for comparative analysis of genetic variation to identify selection. Region II of each of these genes was sequenced from a cross-sectional sample of parasites in an endemic Kenyan population, and the frequency distributions of polymorphisms analysed. A positive value of Tajima's D was observed for eba-175 (D = 1.13) indicating an excess of intermediate frequency polymorphisms, while all other genes had negative values, the most negative being ebl-1 (D = -2.35) followed by ψeba-165 (D = -1.79). The eba-175 and ebl-1 genes were then studied in a sample of parasites from Thailand, for which a positive Tajima's D value was again observed for eba-175 (D = 1.79), and a negative value for ebl-1 (D = -1.85). This indicates that eba-175 is under balancing selection in each population, in strong contrast to the other members of the gene family, particularly ebl-1 and ψeba-165 that may have been under recent directional selection. Population expansion simulations were performed under a neutral model, further supporting the departures from neutrality of these genes. © 2006 Elsevier B.V. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748028816&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleContrasting signatures of selection on the Plasmodium falciparum erythrocyte binding antigen gene familyen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1016/j.molbiopara.2006.05.010en_US
Appears in Collections:Scopus 2006-2010

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