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dc.contributor.authorFederica Verraen_US
dc.contributor.authorWatcharee Chokejindachaien_US
dc.contributor.authorGareth D. Weedallen_US
dc.contributor.authorSpencer D. Polleyen_US
dc.contributor.authorTabitha W. Mwangien_US
dc.contributor.authorKevin Marshen_US
dc.contributor.authorDavid J. Conwayen_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherCentre for Geographic Medicine Researchen_US
dc.contributor.otherMedical Research Council Laboratories Gambiaen_US
dc.identifier.citationMolecular and Biochemical Parasitology. Vol.149, No.2 (2006), 182-190en_US
dc.description.abstractErythrocyte binding antigens of Plasmodium falciparum are involved in erythrocyte invasion, and may be targets of acquired immunity. Of the five eba genes, protein products have been detected for eba-175, eba-181 and eba-140, but not for ψeba-165 or ebl-1, providing opportunity for comparative analysis of genetic variation to identify selection. Region II of each of these genes was sequenced from a cross-sectional sample of parasites in an endemic Kenyan population, and the frequency distributions of polymorphisms analysed. A positive value of Tajima's D was observed for eba-175 (D = 1.13) indicating an excess of intermediate frequency polymorphisms, while all other genes had negative values, the most negative being ebl-1 (D = -2.35) followed by ψeba-165 (D = -1.79). The eba-175 and ebl-1 genes were then studied in a sample of parasites from Thailand, for which a positive Tajima's D value was again observed for eba-175 (D = 1.79), and a negative value for ebl-1 (D = -1.85). This indicates that eba-175 is under balancing selection in each population, in strong contrast to the other members of the gene family, particularly ebl-1 and ψeba-165 that may have been under recent directional selection. Population expansion simulations were performed under a neutral model, further supporting the departures from neutrality of these genes. © 2006 Elsevier B.V. All rights reserved.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleContrasting signatures of selection on the Plasmodium falciparum erythrocyte binding antigen gene familyen_US
Appears in Collections:Scopus 2006-2010

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