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|Title:||Prenylated xanthones as potential antiplasmodial substances|
Walter C. Taylor
Prince of Songkla University
Khon Kaen University
The University of Sydney
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Planta Medica. Vol.72, No.10 (2006), 912-916|
|Abstract:||Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-activity relationships are proposed. © Georg Thieme Verlag KG Stuttgart.|
|Appears in Collections:||Scopus 2006-2010|
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