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Title: Prenylated xanthones as potential antiplasmodial substances
Authors: Wilawan Mahabusarakam
Kunnika Kuaha
Prapon Wilairat
Walter C. Taylor
Prince of Songkla University
Khon Kaen University
Mahidol University
The University of Sydney
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Aug-2006
Citation: Planta Medica. Vol.72, No.10 (2006), 912-916
Abstract: Mangostin, the major xanthone of Garcinia mangostana, and a series of synthetic derivatives were investigated for their in vitro antiplasmodial activity against Plasmodium falciparum. Mangostin itself showed moderate activity, but prenylated xanthones containing alkylamino functional groups exhibited quite potent antiplasmodial activity. Some structure-activity relationships are proposed. © Georg Thieme Verlag KG Stuttgart.
ISSN: 00320943
Appears in Collections:Scopus 2006-2010

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