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Title: Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry
Authors: Facundo M. Fernández
Robert B. Cody
Michael D. Green
Christina Y. Hampton
Rose McGready
Sivong Sengaloundeth
Nicholas J. White
Paul N. Newton
Georgia Institute of Technology
National Center for Infectious Diseases
Shoklo Malaria Research Unit
Ministry of Health
Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine Research Collaboration
University of Oxford
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jul-2006
Citation: ChemMedChem. Vol.1, No.7 (2006), 702-705
Abstract: Vacuum is not the limit: direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature which decreases errors in mass measurement and improves the identification of potentially harmful unknowns. This is important for identifying counterfeit drugs (fake hologram shown). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
ISSN: 18607187
Appears in Collections:Scopus 2006-2010

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