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|Title:||The aging gut motility decay: May symbiotics be acting as "implantable" biologic pace-makers?|
Biokenkyusho Research Laboratory
S. Giuseppe Hospital
Universita degli Studi di Milano
|Keywords:||Biochemistry, Genetics and Molecular Biology;Medicine|
|Citation:||Rejuvenation Research. Vol.9, No.2 (2006), 342-345|
|Abstract:||Motility recording of small and large intestine was performed in old Wistar rats divided into three groups: (a) standard diet, (b) standard diet plus a symbiotic preparation, and (c) standard diet plus a heat-inactivated symbiotic preparation. SCM-III. significantly increased the myoelectric activity of small intestine and colon (p < 0.01 versus [a] and [c]) paralleling "young" values of 4-month-old rats and increased the spike burst frequency in the proximal-distal colon (p < 0.05). SCM-III significantly increased the frequency and duration of spike bursts in the jejunum, transverse-distal colon, and defecation frequency, while decreasing the intervals of migrating motor complex in the colon (p < 0.01) to "young" values with an increased mRNA expression of VIP (p < 0.05). Gut flora manipulation aimed to modulate myoelectric activity can tentatively help reversing age-related motility decay. © Mary Ann Liebert, Inc.|
|Appears in Collections:||Scopus 2006-2010|
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