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Title: The aging gut motility decay: May symbiotics be acting as "implantable" biologic pace-makers?
Authors: Y. Metugriachuk
F. Marotta
K. Pavasuthipaisit
O. Kuroi
J. Tsuchiya
A. Lorenzetti
E. Fesce
E. Minelli
TMC Hospital
Biokenkyusho Research Laboratory
S. Giuseppe Hospital
Universita degli Studi di Milano
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 1-Jun-2006
Citation: Rejuvenation Research. Vol.9, No.2 (2006), 342-345
Abstract: Motility recording of small and large intestine was performed in old Wistar rats divided into three groups: (a) standard diet, (b) standard diet plus a symbiotic preparation, and (c) standard diet plus a heat-inactivated symbiotic preparation. SCM-III. significantly increased the myoelectric activity of small intestine and colon (p < 0.01 versus [a] and [c]) paralleling "young" values of 4-month-old rats and increased the spike burst frequency in the proximal-distal colon (p < 0.05). SCM-III significantly increased the frequency and duration of spike bursts in the jejunum, transverse-distal colon, and defecation frequency, while decreasing the intervals of migrating motor complex in the colon (p < 0.01) to "young" values with an increased mRNA expression of VIP (p < 0.05). Gut flora manipulation aimed to modulate myoelectric activity can tentatively help reversing age-related motility decay. © Mary Ann Liebert, Inc.
ISSN: 15491684
Appears in Collections:Scopus 2006-2010

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