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|Title:||Antifungal azaphilones from the fungus Chaetomium cupreum CC3003|
Khon Kaen University
National University of Laos
King Mongkut's Institute of Technology Ladkrabang
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics|
|Citation:||Journal of Natural Products. Vol.69, No.6 (2006), 891-895|
|Abstract:||Three new azaphilones named rotiorinols A-C (1-3), two new stereoisomers, (-)-rotiorin (4) and epi-isochromophilone II (5), and a known compound, rubrorotiorin (6), were isolated from the fungus Chaetomium cupreum CC3003. Structures were established on the basis of spectroscopic evidence. The absolute configuration of 1 was determined by the modified Mosher's method along with an X-ray analysis of its acetate derivative, as well as by chemical transformation. Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50values of 10.5, 16.7, 24.3, and 0.6 μg/mL, respectively. © 2006 American Chemical Society and American Society of Pharmacognosy.|
|Appears in Collections:||Scopus 2006-2010|
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