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Title: Antifungal azaphilones from the fungus Chaetomium cupreum CC3003
Authors: Somdej Kanokmedhakul
Kwanjai Kanokmedhakul
Pitak Nasomjai
Sysavad Louangsysouphanh
Kasem Soytong
Minoru Isobe
Palangpon Kongsaeree
Samran Prabpai
Apichart Suksamrarn
Khon Kaen University
National University of Laos
King Mongkut's Institute of Technology Ladkrabang
Nagoya University
Mahidol University
Ramkhamhaeng University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jun-2006
Citation: Journal of Natural Products. Vol.69, No.6 (2006), 891-895
Abstract: Three new azaphilones named rotiorinols A-C (1-3), two new stereoisomers, (-)-rotiorin (4) and epi-isochromophilone II (5), and a known compound, rubrorotiorin (6), were isolated from the fungus Chaetomium cupreum CC3003. Structures were established on the basis of spectroscopic evidence. The absolute configuration of 1 was determined by the modified Mosher's method along with an X-ray analysis of its acetate derivative, as well as by chemical transformation. Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50values of 10.5, 16.7, 24.3, and 0.6 μg/mL, respectively. © 2006 American Chemical Society and American Society of Pharmacognosy.
ISSN: 01633864
Appears in Collections:Scopus 2006-2010

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