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Title: Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutase
Authors: Theeraphon Piacham
Chartchalerm Isarankura-Na-Ayudhya
Chanin Nantasenamat
Sakda Yainoy
Lei Ye
Leif Bülow
Virapong Prachayasittikul
Mahidol University
Lunds Universitet
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 24-Mar-2006
Citation: Biochemical and Biophysical Research Communications. Vol.341, No.4 (2006), 925-930
Abstract: Superoxide dismutase (SOD) activities of various metallobacitracin complexes were evaluated using the riboflavin-methionine-nitro blue tetrazolium assay. The radical scavenging activity of various metallobacitracin complexes was shown to be higher than those of the negative controls, e.g., free transition metal ions and metal-free bacitracin. The SOD activity of the complex was found to be in the order of Mn(II) > Cu(II) > Co(II) > Ni(II). Furthermore, the effect of bacitracin and their complexation to metals on various microorganisms was assessed by antibiotic susceptibility testing. Moreover, molecular modeling and quantum chemical calculation of the metallobacitracin complex was performed to evaluate the correlation of electrostatic charge of transition metal ions on the SOD activity. © 2006 Elsevier Inc. All rights reserved.
ISSN: 0006291X
Appears in Collections:Scopus 2006-2010

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