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Title: Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza
Authors: Sudarat Homhual
Hong Jie Zhang
Nuntavan Bunyapraphatsara
Tamara P. Kondratyuk
Bernard D. Santarsiero
Andrew D. Mesecar
Angkana Herunsalee
Wongsatit Chaukul
John M. Pezzuto
Harry H.S. Fong
Mahidol University
University of Illinois at Chicago
Purdue University
Thailand Ministry of Public Health
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Feb-2006
Citation: Planta Medica. Vol.72, No.3 (2006), 255-260
Abstract: A new cyclic 4-hydroxy-dithiosulfonato, bruguiesulfurol (1), as well as two known 4-hydroxydithiolane 1-oxides, brugierol (2) and isobrugierol (3) were isolated from the flowers of Bruguiera gymnorrhiza. With stably-transfected HepG2 cells, the three isolates activated antioxidant response element (ARE) luciferase activation with (EC50) values of 56.7, 3.7 and 1.8 μM, respectively. Compounds 2 and 3 also inhibited phorbol ester-induced NF-κB (nuclear factor-κB) luciferase activity with IC50 values of 85.0 and 14.5 μM, respectively. In addition, compound 2 inhibited enzyme cyclooxygenase-2 (COX-2) activity with an IC50 value of 6.1 μM. The structures of these isolates were determined by spectral data, and that of compound 1 was confirmed by X-ray crystallographic analysis. © Georg Thieme Verlag KG Stuttgart.
ISSN: 00320943
Appears in Collections:Scopus 2006-2010

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