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Title: Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis
Authors: Chanpen Karuwan
Thitirat Mantim
Patcharin Chaisuwan
Prapin Wilairat
Kate Grudpan
Piyada Jittangprasert
Yasuaki Einaga
Orawon Chailapakul
Leena Suntornsuk
Oraphan Anurukvorakun
Duangjai Nacapricha
Mahidol University
Chiang Mai University
Srinakharinwirot University
Keio University
Chulalongkorn University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry;Engineering;Physics and Astronomy
Issue Date: 1-Jan-2006
Citation: Sensors. Vol.6, No.12 (2006), 1837-1850
Abstract: This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixed-potential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 μM, 1.0-100 μM and 0.5-50 μM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method. © 2006 by MDPI.
ISSN: 14248220
Appears in Collections:Scopus 2006-2010

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