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Title: Immunomodulatory effect and quantitation of a cytotoxic glycosphingolipid from Murdannia loriformis
Authors: Weena Jiratchariyakul
Molvibha Vongsakul
Leena Sunthornsuk
Primchanien Moongkarndi
Ammararat Narintorn
Aimon Somanabandhu
Hikaru Okabe
August Wilhelm Frahm
Mahidol University
Fukuoka University
Universitat Freiburg im Breisgau
Keywords: Chemistry;Medicine;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jul-2006
Citation: Journal of Natural Medicines. Vol.60, No.3 (2006), 210-216
Abstract: NMR signal reassignments for a cytotoxic glycosphingolipid compound, 2, β-O-D-glucopyranosyl-2-(2′-hydroxy-Z-6′-enecosamide) sphingosine, isolated from an ethanolic extract of the herb Murdannia loriformis, have been achieved by use of FAB-MS, and 1D and 2D1H and13C NMR. The amount of 2 in the herb juice was quantitatively determined by use of a validated HPLC method (RP-18, MeOH-H2O, UV detection at 210 nm). The immunomodulatory effect of the herb juice and of 2 was proved by means of in vitro cellular immunological assays. Compound 2 at a concentration of 13 nmol L-1stimulated PBMC proliferation and increased the CD 3,4:CD 3,8 ratio in T lymphocytes. © 2006 The Japanese Society of Pharmacognosy and Springer.
ISSN: 18610293
Appears in Collections:Scopus 2006-2010

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