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Title: Comparison of UV spectrophotometric method and high performance liquid chromatography for the analysis of flunarizine and its application for the dissolution test
Authors: Kesarin Busaranon
Worapot Suntornsuk
Leena Suntornsuk
Rangsit University
King Mongkuts University of Technology Thonburi
Mahidol University
Keywords: Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 11-Apr-2006
Citation: Journal of Pharmaceutical and Biomedical Analysis. Vol.41, No.1 (2006), 158-164
Abstract: This study aimed to develop a simple UV spectrophotometric method for the analysis and the dissolution test of flunarizine in capsules. The UV absorbance was both measured directly and by the first derivative measurements at 254 and 268 nm, respectively. The developed methods were validated for their linearity, accuracy, precision, limit of detection (LOD) and limit of quantitation (LOQ) in comparison with the reported HPLC method. The UV spectrophotometric method illustrated excellent linearity (r2> 0.9999) in the concentration range of 6-24 μg/mL. Precision (%R.S.D. < 1.50) and recoveries were good (%R > 99.62). The LOD of direct UV and first derivative measurements were 0.09 and 0.84 μg/mL, respectively, and the LOQ were 0.26 and 2.55 μg/mL, respectively. Results from the assay of flunarizine in capsules by the UV spectrophotometric methods, both direct and first derivative measurements were not significantly different from those of the HPLC method (P > 0.05). Additionally, the method was successfully used for the dissolution test of flunarizine capsule and was found to be reliable, simple, fast, and inexpensive. © 2005 Elsevier B.V. All rights reserved.
ISSN: 07317085
Appears in Collections:Scopus 2006-2010

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