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Title: Inhibitory effect of Thai plant extracts on P-glycoprotein mediated efflux
Authors: Varaporn Buraphacheep Junyaprasert
Noppamas Soonthornchareonnon
Suchitra Thongpraditchote
Teruo Murakami
Mikihisa Takano
Mahidol University
Hiroshima University
Keywords: Chemistry;Pharmacology, Toxicology and Pharmaceutics
Issue Date: 1-Jan-2006
Citation: Phytotherapy Research. Vol.20, No.1 (2006), 79-81
Abstract: Curcuminoids from Curcuma longa L. and extracts of Psidium guajava L., Andrographis paniculata (Burm. f.) Nees, Phyllanthus emblica L. and Solanum trilobatum L. were investigated for their inhibitory effect on P-glycoprotein (P-gp) on the efflux transport of rhodamine 123 (Rho-123) in Caco-2 cells and rat ileum. Of the five tested samples, curcuminoids and an extract of P. guajava showed the highest inhibitory effect on P-gp mediated efflux of Rho-123 in Caco-2 cells. Additionally, they were found to have equal potential in inhibiting Rho-123 efflux transport from serosal to mucosal surfaces of the rat ileum. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN: 10991573
Appears in Collections:Scopus 2006-2010

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