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Title: Ngoye virus: A novel evolutionary lineage within the genus Flavivirus
Authors: Gilda Grard
Jean Jacques Lemasson
Massamba Sylla
Audrey Dubot
Shelley Cook
Jean Francois Molez
Xavier Pourrut
Rémi Charrel
Jean Paul Gonzalez
Ulrike Munderloh
Edward C. Holmes
Xavier de Lamballerie
Faculte de Medecine de Marseille Universite de la Mediterranee
IRD - UR0178
Mahidol University
University of Oxford
Centre International de Recherches Medicales de Franceville
University of Minnesota Twin Cities
Pennsylvania State University
Keywords: Immunology and Microbiology
Issue Date: 1-Nov-2006
Citation: Journal of General Virology. Vol.87, No.11 (2006), 3273-3277
Abstract: By using degenerate primers deduced from conserved patterns in the flavivirus polymerase gene, a novel RNA virus was discovered in Rhipicephalus ticks sampled from members of the family Bovidae in Senegal. It was named Ngoye virus (NGOV) after the location from which it was isolated. Viral particles could be observed by electron microscopy, but isolation in vertebrate or invertebrate cell lines or by intracerebral infection of newborn mice remained unsuccessful. This is atypical of recognized arboviruses. The characterization of 4176 nt of the non-structural genes revealed that NGOV is a novel flavivirus species. It forms a distinct phylogenetic lineage related distantly to previously identified members of the genus Flavivirus. Analysis of genetic data suggested that the processing of the NGOV polyprotein and the organization of its replication complex are similar to those of flaviviruses. Together with other recent data, these findings suggest that a large number of viruses related distantly to 'classical' arthropod-borne flaviviruses remain to be discovered. © 2006 SGM.
ISSN: 00221317
Appears in Collections:Scopus 2006-2010

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