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Title: Beijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitis
Authors: Maxine Caws
Guy Thwaites
Kasia Stepniewska
Nguyen Thi Ngoc Lan
Nguyen Thi Hong Duyen
Nguyen Thi Phuong
Mai Nguyet Thu Huyen
Phan Minh Duy
Tran Huu Loc
Tran Thi Hong Chau
Dick Van Soolingen
Kristin Kremer
Nguyen Vinh Van Chau
Nguyen Tran Chinh
Jeremy Farrar
Brighton and Sussex University Hospitals NHS Trust
Pham Ngoc Thach Hospital for Tuberculosis and Lung Diseases
Mahidol University
Churchill Hospital
National Institute of Public Health and the Environment
Keywords: Immunology and Microbiology;Medicine
Issue Date: 1-Nov-2006
Citation: Journal of Clinical Microbiology. Vol.44, No.11 (2006), 3934-3939
Abstract: Multidrug-resistant tuberculous meningitis is fatal without rapid diagnosis and use of second-line therapy. It is more common in human immunodeficiency virus (HIV)-positive patients. Beijing genotype strains of Mycobacterium tuberculosis are associated with drug resistance, particularly multidrug resistance, and their prevalence is increasing worldwide. The prevalence of Beijing genotype strains among Mycobacterium tuberculosis isolates from the cerebrospinal fluid of HIV-positive (n = 35) and HIV-negative (n = 187) patients in Ho Chi Minh City was determined. The Beijing genotype was significantly associated with HIV status (odds ratio [OR] = 2.95 [95% confidence interval {CI}, 1.38 to 6.44]; P = 0.016), resistance to any drug (OR = 3.34 [95% CI, 1.87 to 5.95]; P < 0.001) and multidrug resistance (Fisher's exact test; P = 0.001). The association of the Beijing genotype with drug resistance was independent of HIV status. This is the first report of Beijing genotype association with HIV status, which may be an association unique to tuberculous meningitis. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
ISSN: 00951137
Appears in Collections:Scopus 2006-2010

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