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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/23302
Title: Position-specific polymorphism of Plasmodium falciparum stuttering motif in a PHISTc PFI1780w
Authors: Thanat Chookajorn
Daniel L. Hartl
Harvard University
Mahidol University
Keywords: Immunology and Microbiology
Issue Date: 1-Oct-2006
Citation: Experimental Parasitology. Vol.114, No.2 (2006), 126-128
Abstract: Several genes of Plasmodium falciparum are positively selected due to the pressure from the host immune system. This is a pattern completely opposite to that found in most housekeeping genes, which have few synonymous mutations. The discrepancy is an important topic in Plasmodium biology. We searched for unique polymorphism patterns in P. falciparum and identified a repetitive Stuttering motif in PFI1780w which was recently grouped as a gene in the PHIST family. The repeat has a position-specific polymorphism pattern in the otherwise highly conserved gene. Its mutations are limited to only one small region, and they are not consistent with replication slippage or gene conversion commonly found in low complexity regions. The repeat variation was analyzed in different strains of P. falciparum. The PFI1780w Stuttering motif can be a model to study gene diversification and used as a tool for strain typing. © 2006 Elsevier Inc. All rights reserved.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748521844&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/23302
ISSN: 10902449
00144894
Appears in Collections:Scopus 2006-2010

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