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Title: Genetic diversity of Plasmodium vivax in Kolkata, India
Authors: Jung Ryong Kim
Mallika Imwong
Amitabha Nandy
Kesinee Chotivanich
Apichart Nontprasert
Naowarat Tonomsing
Ardhendu Maji
Manjulika Addy
Nick P J Day
Nicholas J. White
Sasithon Pukrittayakamee
Mahidol University
Calcutta School of Tropical Medicine
Churchill Hospital
Thailand Environmental Institute
Keywords: Immunology and Microbiology;Medicine
Issue Date: 14-Aug-2006
Citation: Malaria Journal. Vol.5, (2006)
Abstract: Background: Plasmodium vivax malaria accounts for approximately 60% of malaria cases in Kolkata, India. There has been limited information on the genotypic polymorphism of P. vivax in this malaria endemic area. Three highly polymorphic and single copy genes were selected for a study of genetic diversity in Kolkata strains. Methods: Blood from 151 patients with P. vivax infection diagnosed in Kolkata between April 2003 and September 2004 was genotyped at three polymorphic loci: the P. vivax circumsporozoite protein (pvcs), the merozoite surface protein 1 (pvmsp1) and the merozoite surface protein 3-alpha (pvmsp3-alpha). Results: Analysis of these three genetic markers revealed that P. vivax populations in Kolkata are highly diverse. A large number of distinguishable alleles were found from three genetic markers: 11 for pvcs, 35 for pvmsp1 and 37 for pvmsp3-alpha. These were, in general, randomly distributed amongst the isolates. Among the 151 isolates, 142 unique genotypes were detected the commonest genotype at a frequency of less than 2% (3/151). The overall rate of mixed genotype infections was 10.6%. Conclusion: These results indicate that the P. vivax parasite population is highly diverse in Kolkata, despite the low level of transmission. The genotyping protocols used in this study may be useful for differentiating re-infection from relapse and recrudescence in studies assessing of malarial drug efficacy in vivax malaria. © 2006 Kim et al; licensee BioMed Central Ltd.
ISSN: 14752875
Appears in Collections:Scopus 2006-2010

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