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dc.contributor.authorNutjeera Intasaien_US
dc.contributor.authorSabine Maien_US
dc.contributor.authorWatchara Kasinrerken_US
dc.contributor.authorChatchai Tayapiwatanaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Manitobaen_US
dc.contributor.otherChiang Mai Universityen_US
dc.date.accessioned2018-08-20T07:01:18Z-
dc.date.available2018-08-20T07:01:18Z-
dc.date.issued2006-07-01en_US
dc.identifier.citationInternational Immunology. Vol.18, No.7 (2006), 1159-1169en_US
dc.identifier.issn14602377en_US
dc.identifier.issn09538178en_US
dc.identifier.other2-s2.0-33745238125en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745238125&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/23319-
dc.description.abstractCD147 is a broadly expressed cell-surface molecule and serves as a signaling receptor for extracellular cyclophilins. CD147 also appears to interact with immune cells, but its counter-receptor on these cells has not been clearly described. In the present report, we displayed multiple copies of the CD147 extracellular domain (CD147Ex) on VCSM13 phage to study the interaction of CD147 with its ligand. Recognition of phage containing fusion protein of CD147Ex and gpVIII (CD147Ex phage) by four different anti-CD147 mAbs indicated that at least parts of the CD147 are properly folded. Specific binding of CD147Ex phage to various cell types was demonstrated by flow cytometry. Morphological changes, however, were observed only in U937, a monocytic cell line, after 24 h incubation with multivalent CD147Ex phage. After 48 h, U937 cell propagation ceased. Staining with annexin V and the presence of cleaved caspase-3 indicated that many of the CD147Ex phage-treated cells had lost viability through apoptotic cell death. The above results suggest that CD147 induces apoptosis in U973 cells and that at least a portion of this cell death program involves a caspase-dependent pathway. © 2006 Oxford University Press.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33745238125&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.titleBinding of multivalent CD147 phage induces apoptosis of U937 cellsen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1093/intimm/dxl050en_US
Appears in Collections:Scopus 2006-2010

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